What Are the Uses of Stachyose Powder?

Sucrose is a functional oligosaccharide that naturally exists in many plants in the family of Labiatae, Leguminosae, and Genisteinae, especially in the highest content in the genus Sucrose in the family of Labiatae. The structure of fructose is clear, molecular formula C24H42O21, molecular weight 666.59, it is composed of glucose group of sucrose with α-1,6 glycosidic linkage to dolactose, which belongs to α-glycosylated galactose (α-GOS). As a kind of functional oligosaccharide, Sucrose is a natural bifidogenic factor. As a functional oligosaccharide, fructose is a natural bifidogenic factor, which has the effects of regulating the balance of intestinal flora, regulating the immune system and improving the physiological health of human beings, and is a high-quality functional food ingredient, so the report gives an overview of the research on the physiological functions of fructose in recent years and the prospect of its application.

1 Regulation of intestinal flora

According to the Procedures and Test Methods for Functional Evaluation of Health Food, the Food Hygiene Supervision and Inspection Institute of the National Health and Family Planning Commission of China conducted animal experiments on the regulation of intestinal flora with fructose sent by the China National Institute of Food and Fermentation Industry (CNIFFVI). The results showed that the number of Bifidobacterium and Lactobacillus in the intestinal tract of mice increased significantly after three doses (0.25g/kg-bw, 0.5g/kg-bw, 1.5g/kg-bw) of Sucrose (see Table 1), and the difference was highly significant (p ≤ 0.01), which indicated that Sucrose had the effects of regulating the intestinal flora and proliferating Bifidobacterium and Lactobacillus.

Gao Peng et al. selected 250 subjects divided into five groups and gave 0, 0.5, 3.0, 5.0 and 10.0g of fructose per person per day respectively. After 60d of trial consumption, through the analysis of general safety indexes and functional indexes of 30d of trial consumption, the following conclusions were made: 0.5g of fructose per day could increase bifidobacteria in the intestine after 30d of consumption; 3g of fructose per day could increase bifidobacteria and lactobacilli in the intestine after 30d of consumption; there was no adverse effect on the health of all the trial subjects after 60d of fructose consumption. After 30d of consumption, there was a significant increase of Bifidobacteria and Lactobacillus in the intestinal tract; there was no adverse effect on the health of all the test subjects after 60d of consumption.

Through proliferation of bifidobacteria, lactobacilli and fructose, it has some indirect physiological functions on human body, which are manifested in the protection of liver, the promotion of lead excretion, the relief of constipation and the prevention of diarrhea, the lowering of blood pressure and blood lipids, and the inhibition of the growth of harmful bacteria, and so on.

1.1 Prevention of hepatic encephalopathy and treatment of liver cirrhosis

Li Ruijun et al. studied the preventive effect of fructose on subclinical hepatic encephalopathy (SHE), which can be treated with lactulose and other clinical treatments for hepatic encephalopathy (HE), the pathogenesis of which is not yet fully understood, but ammonia toxicity plays a very important role in both treatment and prevention. The Chinese medicine extract fructose and lactulose are both oligosaccharide molecules. It has been shown that fructose is not broken down by human digestive enzymes and is not absorbed by the intestinal tract. When taken orally, it decreases intestinal pH and increases intestinal peristalsis, thus reducing the absorption of ammonia in the intestinal tract. At the same time, fructose can provide energy, promote the body's own multiple bifidobacteria to grow exponentially, so that the intestinal indole and other amines can be reduced, thus reducing the occurrence of endotoxemia. In the present study, we used fructose instead of lactulose as a preventive drug for HE, and carried out the evoked potential and blood ammonia examination in the same way, and the results showed that the oral administration of fructose to rabbits in the production of rabbit model of acute liver failure could prevent and alleviate the effects of HE as well as lactulose. The application of the Chinese medicine extract of fructose in the prevention and treatment of SHE is expected to have a good application prospect because of the rich source and low value of Chinese medicines.

Li Liqiu et al. studied the effect of fructose in the treatment of liver cirrhosis. Cirrhosis is a common disease and one of the major causes of death in China, due to the complexity of the pathogenesis, and the limited effect of many therapeutic means. Most studies have shown that cirrhosis is often accompanied by intestinal endotoxemia and intestinal flora dysbiosis. Sucrose can accelerate the excretion of toxic metabolic substances from the intestinal tract, reduce the process of reabsorption of toxic metabolic substances into the bloodstream and their bioconversion by the liver, and greatly reduce the burden of liver decomposition of toxins. At the same time, fructose can provide energy, promote the body's own variety of bifidobacteria to grow exponentially, so that the intestinal indole and other amines to reduce, thus reducing the occurrence of endotoxemia. The results of this experiment, which used fructose, showed that fructose could effectively reduce the plasma AST, ALT, and endotoxin levels in cirrhotic rats (P＜0.01), and it also had a significant improvement in liver histopathology. The experiment also showed that fructose could correct the dysbiosis in the cirrhosis model group, act as a probiotic, prevent the growth of spoilage bacteria, and promote the growth of bifidobacteria and lactobacilli. The effect was more obvious in the prevention group (P＜0.01), indicating that early application was more effective. China is a country with high incidence of hepatitis and cirrhosis, and hepatic encephalopathy is often the cause of death. Sucrose, an extract of traditional Chinese medicine, can adjust the intestinal bacterial flora, which can have a better therapeutic effect on cirrhosis and reduce its complications, and provide a theoretical basis for the treatment of cirrhosis in clinical practice.

1.2 Promotion of lead elimination

When lead enters the human body, it interferes with the metabolism of ions such as iron, zinc and calcium, which are essential to the human body, thus causing the human body to show signs of calcium, iron and zinc deficiencies. Data show that calcium, iron, zinc and B vitamins are related to the absorption of lead, and it is found that the combination of these substances can reduce the absorption of lead in the small intestine. Oral administration of fructose can significantly increase the proliferation of bifidobacteria, which not only produce various vitamins such as VB1, VB2, VB6, VB12, niacin and folic acid for the body's needs, but also ensure the supply of vitamins through the inhibition of certain vitamin-degrading bacteria. For example, it can inhibit the thiaminolytic bacillus that breaks down VB1. On the one hand, L-lactic acid is produced by Bifidobacterium bifidum after decomposition of fructose, and L-lactic acid in the cecum binds calcium to increase its solubility, leading to enhanced calcium absorption. On the other hand, fructose can promote the synthesis of B vitamins, thus greatly reducing the intestinal absorption of lead. In 2003, the Institute of Nutrition and Food Safety of the Chinese Center for Disease Control and Prevention (CDC) conducted a human dietary test on Tongkangbao brand lead-eliminating oral liquid, which uses fructose as the main raw material, in order to promote the elimination of lead. The urinary lead excretion rate of the test group increased significantly higher than the urinary calcium and zinc excretion rates (P＜0.001). The clinical indicators of hemoglobin, red blood cells, white blood cells, total serum protein, albumin, glutamic oxaloacetic aminotransferase, glutamic alanine aminotransferase, urea nitrogen and urinary routine before and after the test feeding were all in the normal range, which indicated that Tongkangbao Brand Oral Lead Elimination Liquid did not have any adverse effect on the health of the test subjects.

1.3 Relief of constipation and control of diarrhea

The fermentation of fructose by bifidobacteria produces a large amount of short-chain fatty acids, which can stimulate intestinal peristalsis, increase the wetness of feces, and maintain a certain osmotic pressure through the massive growth of the bacteria, thus preventing feces from accumulating in the large intestine, and forming hard and dry lumps of feces after the water has been absorbed, thus preventing the occurrence of constipation.

There may be two mechanisms for the prevention of diarrhea: one is the adhesion and protective effect of fructose on intestinal mucosal epithelial cells; the other is that fructose can proliferate beneficial bacteria and inhibit the growth of harmful bacteria. It has been reported in foreign literature that the structure of Gal-α-1,6-Gal gives fructose the property of adhesin, which can directly adhere to the intestinal epithelial cells after reaching the intestinal tract and enhance the intestinal immunity and protect the host from pathogenic bacteria.

1.4 Lowering of blood pressure and blood lipids

The Institute of Aeronautical Medicine of Air Force General Hospital has observed 83 cases of patients with high blood lipids taking fructose preparations, each taking 7.2g of fructose per day for 8w, the result was that serum cholesterol and LDL cholesterol were significantly reduced (P<0.05). Observations on hypertensive patients also proved that fructose has the effect of lowering blood pressure: patients were given 10g of fructose per day for 6w, and their diastolic blood pressure was lowered by 799.7Pa on average.

The hypotensive and hypolipidemic mechanism of fructose may also be realized by the proliferation of bifidobacteria. In the study of Zhang Leiyi[8] from Jiamusi Medical College, the effect of Bifidobacterium complex preparation on lipid metabolism in patients with hyperlipidemia was observed, and the results showed that Bifidobacterium could reduce serum cholesterol and di-glycerides, and improve the effect of lipid metabolism disorders. Research on microecology has found that certain beneficial intestinal bacteria can indeed reduce cholesterol to steroid and excrete it from the body, interfere with and reduce the reabsorption of bile acids and cholesterol, so as to reduce cholesterol in the blood and liver.

1.5 Inhibit the growth of harmful bacteria

The bacteriostatic effects of fructose can be categorized into direct and indirect bacteriostatic effects. The direct bacteriostatic effect allows the use of fructose in the production of anti-caries and anti-infectious foods and medicines, while the indirect bacteriostatic effect is mainly realized through the proliferation of bifidobacteria.

Anti-bacteria: Dental caries is formed by oral microorganisms, especially Streptococcus mutans, which ferment sugar and multiply, produce acid and erode teeth. Sucrose cannot be used as a suitable substrate for oral microorganisms, so it cannot be absorbed and utilized, and will not cause dental caries, so it can be used in various kinds of food to prevent dental caries.

Direct Inhibition of Infections: Researchers at the University of Alabama School of Microbiology found that some infectious bacteria were unable to grow in the presence of fructose. After genetically altering Streptococcus pneumoniae to make it more resistant, these highly infectious microorganisms lost their ability to grow and reproduce in the presence of fructose. In another set of experiments at the Faculty of Microbiology and Filtrative Microbiology of Sassari University, Trichomonas vaginalis (the bacterium that causes vaginal infections) could not survive in the presence of fructose.

Indirect bacterial inhibition: Oral fructose 3g/d can significantly proliferate Bifidobacterium bifidum, which has an inhibitory effect on spoilage bacteria and pathogenic bacteria, pathogenic Escherichia coli, Staphylococcus aureus, Shigella dysenteriae, Salmonella typhimurium, anamorphosis, Pseudomona albicans, and so on. The antimicrobial effect of bifidobacteria not only inhibits saprophytes by lowering the pH value of the intestinal tract due to the production of various organic acids, but also produces an antimicrobial substance, bifidin, which inhibits some saprophytes (Staphylococcus aureus, Micrococcus yellows) when the bacterium grows up to a certain stage. Bifidobacteria can also decompose coupled bile acids into free bile acids, which have a stronger inhibitory effect on bacteria.

2 Regulation of immune function

Sucrose has Gal-α-1,6-Gal structure, and some foreign studies have confirmed that this α-Gal structure participates in immunity, adsorption between pathogens and cells and other biological processes on the basis of the molecular mechanism of sympathetic response of the coordinating base receiver, which makes Sucrose has the functions of preventing pathogen infection, neutralizing toxins and regulating the immune system.

2.1 Atopic dermatitis inhibition

Sato Toshiro et al. in Japan concluded that fructose has a significant inhibitory effect on atopic dermatitis (AD). In their U.S. Patent Office Publication Antiallergic composition (Patent No. 7166582), they demonstrated the significant inhibitory effect of Sucralose on AD. Five out of six mice in the control group showed signs of dermatitis, while the seltzerose-dosed group did not show any signs. After six to eight weeks of grouping, the control mice showed signs of dermatitis not only on the face but also on the ears, whereas the seltzer group showed no signs. The dermatitis recordings showed that the inhibitory effect of seltzerose was significant.

Because atopic dermatitis is thought to be associated with both direct sensitization and delayed hypersensitivity, it is hypothesized that there are two mechanisms of expression for the anti-atopic dermatitis effect of fructose: either fructose acts on intestinal microbes to enhance intestinal immunity, or fructose may act directly on intestinal immune cells.

2.2 Arthritis inhibition

Reactive arthritis is an acute, non-suppurative arthritis secondary to infection elsewhere in the body. Three-quarters of patients carry the HLA-B27 gene, and studies of the role of HLA-B27 in the development of reactive arthritis have found that neutrophil activity is increased in HLA-B27-positive patients, which may enhance the immune response to pathogenic bacteria. At the same time, HLA-B27 prolongs the survival of intracellular pathogens, thereby increasing T-cell reactivity to the pathogens and their antigenic peptides. Collagen in- duced arthritis (CIA) is a polyarticular inflammatory disease induced by immunizing rodents with type II collagen (CII). It causes symptoms and arthropathology similar to rheumatoid arthritis (RA) (synovial hyperplasia, cellular infiltration, cartilage erosion, bone resorption and remodeling).

A functional study of α-GOS by Takatoshi Fujita and Eriko Kikuchi in Japan showed that oral administration of α-GOS treatment significantly inhibited reactive arthritis in wister mice. A significant inhibitory effect on arthritis was observed on the 15th or 18th day of oral administration of 1g/kg.bw or 3g/kg-bw α-GOS to wister mice. In the collagen-induced arthritis experiment, mice were fed 2g/kg-bw α-GOS daily, and a significant reduction of arthritic symptoms was observed on the 28th day. α-GOS significantly suppressed the symptoms of erythema and edema, and histopathological studies showed that oral administration of α-GOS was beneficial to patients with reactive arthritis and collagen-induced arthritis. In animal experiments, nitrite has been shown to play an important role in the development of rheumatoid arthritis, and nitrite synthase inhibitors can effectively inhibit arthritis, while α-GOS can reduce the level of nitrite in reactive arthritis mice, which may be one of the reasons for the inhibition of arthritis by α-GOS. α-GOS can stimulate peritoneal macrophages by regulating the intestinal flora, and inhibit the production rate of IL-1α. α-GOS stimulates peritoneal macrophages by regulating intestinal flora and inhibits IL-1α production. Although the mechanism of arthritis inhibition by α-GOS has not yet been fully clarified, the results of the experiments show that α-GOS, represented by fructose, is a functional food with great potential for the treatment of arthritis.

2.3 Suppression of hyperacute rejection

Zhan Jinbiao et al. proposed a method for the application of fructose in the preparation of drugs against hyperacute rejection induced by porcine-human xenotransplantation, and provided the application of fructose in the preparation of drugs against hyperacute rejection induced by porcine-human xenotransplantation. The binding of preexisting natural antibodies in the human body to the pig cell surface antigen Gal-α-1,3-Gal is the main cause of hyperacute rejection. Sucrose, a naturally occurring functional oligosaccharide with α-Gal spatial structure, was shown to bind preexisting anti-Gal-1,3-Gal antibodies or GS-I-B4-specific antibodies in human serum to porcine erythrocytes in the test of inhibition of GS-I-B4 (West African monocotyledonous bean agglutinin, which binds to Gal-α-1,3-Gal specifically) and the test of inhibition of human serum to porcine red blood cells, suggesting that it can pre-emptively bind to preexisting anti-Gal-1,3-Gal antibodies or GS-I-B4-specific antibodies in human serum. It is shown that the fructose can specifically bind to and inactivate the pre-existing anti-Gal-α-1,3-Gal antibodies or GS-I-B4 in human serum, thus inhibiting the occurrence of super-acute rejection reaction. At the same time, fructose is safe, non-toxic, and can be directly consumed, which is expected to be developed into a new drug against the super-acute rejection reaction of porcine organ allograft.

3 Anti-tumor effects

As early as in the early 1950s, the United States began to establish an anticancer drug screening system, and in the following decades, more and more researches have been conducted on the use of cultured cell lines as an in vitro anticancer drug screening system. Many scholars at home and abroad have investigated the inhibitory effect of fructose on the growth of cancer cells through in vitro cytological experiments, and the results show that fructose has obvious inhibitory effect on colon, lung, laryngeal, liver, and gastric cancer cells. However, the anti-tumor mechanism of fructose is still unclear, and further experimental studies are needed.

Zhong Xianfeng from the Affiliated Hospital of Jiangnan University[22] and other researchers investigated the effect and mechanism of silver-striped sultanasucrose in inhibiting the proliferation of human colon cancer Caco-2 cells. The inhibitory effect of silver-striped sultanasucrose on the proliferation of Caco-2 cells was analyzed by using a serum-free medium for the cultivation of Caco-2 cells, and the effect of silver-striped sultanasucrose on apoptosis of Caco-2 cells was investigated by flow cytometry, and the degree of cell damage was analyzed by detecting the LDH release rate. The degree of cell damage was analyzed by measuring the LDH release rate. The results showed that the growth inhibitory effect of silver-striped sultanate on Caco-2 cells was dose- and time-dependent. The results of Annexin-V-PI double staining suggested that the apoptotic rate of Caco-2 cells increased with the increase of silver-striped sultanate concentration, and the comparison of the LDH release rate of Ca- co-2 cells of the experimental groups revealed that silver-striped sultanate inhibited the reduction of pyruvate to lactate in Caco-2 cells. At the same time, comparing the LDH release rate of Ca- co-2 cells in each experimental group, it was found that Ginkgo biloba inhibited the ability of Caco-2 cells to reduce pyruvic acid to lactic acid, restricted the energy pathway of Caco-2 cells, affected the cell cycle, and then led to apoptosis, which indicated that the inhibition of the cellular energy pathway and the "starvation of the cells" might be one of the mechanisms of the anti-tumor effect of Ginkgo biloba.

Jia Shaohua[23] and others investigated the effects of fructose on the growth of human hepatocellular carcinoma HepG-2 cells and human gastric cancer SGC-7901 cells by using MTT assay and Taipan blue assay, and the experimental results showed that fructose could inhibit the proliferation of tumor cells. The in vivo combined effect of cyclophosphamide on the tumor weight of H22 tumor-bearing mice was investigated, and the results showed that fructose could enhance the tumor inhibitory effect of cyclophosphamide dose-dependently, and fructose has anti-tumor effects both in vivo and in vitro.

Wu Weihong examined the cancer inhibitory activities of trehalose, mannose and cotton candy using Hep-2 laryngeal and PG-lung cancer cell lines. The experimental results showed that there was a dose-dependence of the inhibitory effects of trehalose and mannose on Hep-2 laryngeal cancer cells, and the inhibitory rate increased with the increase of the concentration, while the inhibitory rate of trehalose and mannose on Hep-2 laryngeal cancer cells was higher than trehalose at the concentration range of 10~1000 μg/mL and similar at other concentration conditions. At the same time, in the concentration range of 10~1000μg/mL, the inhibition rate of Hep-2 laryngeal cancer cells was higher than that of trehalose, and the degree of inhibition was similar in other concentration conditions. In the concentration of 1000μg/mL, the inhibition rate of trehalose and mannose on Hep-2 laryngeal cancer cells could reach 26%, while that of cotton candy only showed a tendency to inhibit, and the difference of its OD value was not significant when compared with that of the control group (P>0.05). The inhibitory effects of trehalose, mannose and cotton candy on lung cancer cells were dose-dependent and increased with the increase of concentration. The inhibitory effects of trehalose, mannose and cotton candy on lung cancer cells were dose-dependent and increased with the increase of the concentration, and the inhibitory effects of trehalose on lung cancer cells were the strongest, followed by mannose, and cotton candy was the weakest. At a concentration of 1000 μg/mL, the inhibition rates of fructose, mannose and raffinose on PG lung cancer cells were 38.17%, 23.84% and 6.16%, respectively. The antimetastatic mechanism of oligosaccharides or glycoconjugates may be to intervene in the glycosylation of cancer cells and inhibit the synthesis of metastasis-related sugar chains. Wu Weihong hypothesized that mannans may exert their inhibitory effects by affecting the structural changes of the glycoconjugates on the surface of cancer cells, and the structural units of mannans are contained in fructose but not in marshmallow. The mechanisms of inhibition of the growth of cancer cells by mannans and fructose in vitro may also include: direct effect on succinate dehydrogenase, increasing the expression of the P53 gene, and affecting the expression of oncogenes c-myc and c-fos. fos.

4 Hypoglycemic effect

Diabetes mellitus has become a worldwide metabolic disease that seriously jeopardizes the health of human beings and is divided into two main types: type 1 diabetes mellitus and type 2 diabetes mellitus, with type 2 diabetes mellitus accounting for more than 90% of the total number of diabetes mellitus. type 1 diabetes mellitus is mainly characterized by the destruction of pancreatic islet β-cells and the lack of insulin in the blood, which requires the long-term application of insulin therapy, whereas type 2 diabetes mellitus is a non-insulin-dependent type. At present, there are about 150 million diabetic patients in the world, and the World Health Organization predicts that the number of diabetic patients may double by 2025, and the patients are mainly concentrated in Asian countries such as India and China. At present, there are more than 40 million diabetic patients in China, and the incidence of diabetes will continue to grow with the improvement of the living standard of our people.

Sucrose is the main component of Dihuang, a traditional Chinese medicine used for the treatment of thirst-quenching disease in China, and researchers from Peking Union Medical College, Lanzhou General Experimental Hospital of Lanzhou Military Region, and the Academy of Military Medical Sciences have reported on the hypoglycemic effect of the sucrose component of Dihuang and its mechanism.

Zhang Ruxue et al. studied the changes of glucose metabolism in aged rats and the improvement effect of Dihuang Oligosaccharides on it. The results showed that while the proliferation capacity of splenic lymphocytes decreased in aged rats, the content of hepatic glycogen increased, the level of plasma insulin increased, and the level of plasma corticosterone decreased, but the level of blood glucose was still within the normal compensatory range. After 2 months of oral administration of Dihuang Oligosaccharide with fructose as the main ingredient, while improving the immunocompromised function of aged rats, it basically reversed the impaired glucose metabolism and brought it to normal; the elevated hepatic glycogen was converted to normal, the elevated plasma insulin level tended to decrease, and the declining plasma corticosterone level showed a tendency to increase.

Qianjin Huanglianwan can reduce fasting blood glucose and lipid levels, improve glucose tolerance and insulin resistance in diabetic rats. Han Yuwei et al. investigated the effects of berberine and fructose, the functional components of Qianjin Huanglianwan, on the glucose-lipid metabolism and intestinal flora of diabetic mice, and the results showed that berberine combined with fructose can significantly improve glucose-lipid metabolism of diabetic KKAy mice, with a more favorable effect than that of a single ingredient. The results of the study showed that berberine combined with Sucrose could significantly improve the disorders of glycolipid metabolism in diabetic KKAy mice, and the effect was more superior than that of single ingredient, and the mechanism may be related to the promotion of intestinal probiotics.

Wu Weihong studied the hypoglycemic activity of fructose by examining the changes of blood glucose and hepatic glycogen content in a mouse diabetes model induced by tetracycline. The experimental results showed that the blood glucose value of the tetracycline model group was significantly higher than that of the null control group (P<0.01), and the blood glucose value of the three dosage groups (50, 100, and 200mg/kg) was significantly reduced compared with that of the model group and approached the normal blood glucose level, suggesting that fructose has the efficacy of lowering blood glucose in experimental diabetic mice, and its hypoglycemic activity may be achieved by promoting the synthesis of liver glycogen. The blood glucose values of the three dosage groups (50, 100, 200 mg/kg) were significantly lower than those of the model group, and were close to the normal blood glucose level, suggesting that the hypoglycemic activity of Sucralose can lower the blood glucose of experimental diabetic mice, and its hypoglycemic activity may be realized by promoting the synthesis of liver glycogen.

5 Moisturizing skin care effects

The efficacy test report of the evaluation of moisturizing efficacy of fructooligosaccharides conducted by the Beijing Key Laboratory of Plant Resources Research and Development of Beijing Technology and Business University shows that fructooligosaccharides have a good moisturizing ability, which includes increasing the water content of the stratum corneum of the skin as well as decreasing the amount of water loss from the stratum corneum.

The structural characteristics of fructose determine its ability to bind water molecules well, which can fully lock the water and reduce water loss, it is an excellent moisturizing additive, which belongs to the closed type moisturizing agent. Moreover, fructose has good solubility and is not irritating to the skin, and its use in cosmetic products and skin cleansing agents can improve the roughness of the skin and produce a sense of smoothness to the skin, and its improvement is obvious and has no side effects. In the test on the moisturizing effect of 2% of the cosmetics, the result of the test is that the hydration rate increased by 9.14 in 4h and the water loss rate decreased by 1.42 in 4h. As can be seen from Table 2, as a moisturizing additive, after application, the water content of the skin stratum corneum increased significantly, and the amount of water loss was also reduced, thus showing that the tartaric acid is an excellent moisturizing agent.

The patent "Application of Oligosaccharides to Stimulate the Production of β-Endorphins" (Chinese Patent No. 200810179821.0), filed by the French group LVMH, relates to the application of an ashwagandha bean extract containing fructose and/or chickpea glycerol as an active agent in the preparation of cosmetic compositions for treatments that exert a localized pain-relieving effect. The patent mentions that oligosaccharides containing 2-6 sugars and at least two galactose units (represented by fructose, see Table 3 for cytological results) stimulate the production of β-endorphins in the skin and significantly stimulate the production of β-endorphins by skin keratinocytes. Cosmetics or dermatological preparations with added fructose can take care of sensitive skin, overcome skin allergies and maladjustments, keep the skin in a healthy state and have a smooth skin, anti-irritation, anti-itch or local pain relief.

6 Prospects for the development and application of fructose

In the field of health care application, it has the efficacy of regulating intestinal flora, laxative, lowering blood lipid, protecting liver, regulating immunity, etc. With good processing performance, it is suitable for the development of dosage forms such as punch, capsule, tablet, oral liquid, powder, etc., and it has a broad application prospect in the big health industry; in the field of topical skin care, the moisturizing and skin care efficacy of fructus thujaplicatus can be applied to the moisturizing and antiallergenic cosmetic products, which is natural and has no side effect, and it is the natural plant extract with excellent concept and functionality.