Hops Extract 5% Xanthohumol

What is Hops Extract?

Hops Extract is produced from hops, a natural mulberry plant, using liquid carbon dioxide extraction technology at near room temperature. It can give beer a special bitter taste and unique flavor and has certain antiseptic properties. It is known as the "soul of beer" and can be used as food additives as well as antioxidants in medicine, cosmetics, health food, and food.

Green Spring Technology supplies Hops Extract 5% Xanthohumol of good solubility, which maintains the original taste and color of the raw material. Its solvent residues, heavy metals, plasticizers, and pesticide residues follow international standards such as EP, JP, and USP.

Green Spring Technology implements the highest international industry standards, complying with EU EC396, EU 2023/915 standards, and the highest solvent residue standards. It has independent testing laboratories and advanced testing instruments to  control the product quality.

Established in 2000, Green Spring is committed to providing customers with natural, safe, and organic plant extracts. It has obtained Halal, Kosher, COSMOS, BRC, IFS, FDA, ISO, and many other certifications. Green Spring can provide authoritative third-party testing reports.

Specification: 

Regulation:

It conforms to EU regulations.

Benefits:

Improvement of Metabolism

Studies have demonstrated that xanthohumol (XN) isolated from hops (Humulus lupulus L.) extracts and its derivative tetrahydroxanthohumol (TXN) ameliorate the adverse metabolic effects of an obesogenic diet in mice, but the mechanisms involved are not clear.

The researchers used a mouse model of diet-induced obesity and metabolic disease, in which 10 mice were randomly assigned to one of five groups (Figure 2): low fat diet (LFD), high fat diet (LFD), high fat diet (HFD) supplemented with low levels of XN (0.035%), high levels of XN (0.07%), and HFD supplemented with TXN (0.07%). HFD with TXN (0.035%) for 16 weeks.

By measuring the transcriptome of the liver, ileum, and epididymal adipose tissue (adipose tissue), the composition of the microbiome in the feces, the concentration of bile acids in the feces, and phenotypic parameters associated with metabolic disorders in these mice, it was found that TXN was more effective than XN in restoring metabolic alterations induced by an obese diet.

Antioxidant

Hops have a relatively strong antioxidant effect. According to research, the total antioxidant use of hops is related to the polyphenol flavanols in them. Experiments in mice have also confirmed that taking polyphenols from hops extracts can significantly reduce the content of the peroxidation product malondialdehyde and greatly enhance the vitality of the three active components of the antioxidant enzymes superoxide dismutase, glutathione peroxidase, and catalase, thus integrally enhancing the antioxidant capacity.

Alleviates Osteoporosis

Numerous studies have shown that hops can enhance bone density and promote bone cell production. Osteoporosis is a systemic bone metabolic disease characterized by decreased bone mass and destruction of bone microstructure. In Europe, hops extract is used to treat postmenopausal osteoporosis. In recent years, the role of hops in the prevention and treatment of osteoporosis has received widespread attention, and it may be able to prevent and treat osteoporosis by maintaining bone homeostasis through the exertion of estrogen-like effects, mitigating oxidative damage, and regulating the balance of bone formation and bone resorption.

The functional components that play this role are xanthohumol, serpentinone and humulone, all of which promote bone formation and inhibit bone resorption. According to research, some drugs used to treat gastrointestinal diseases, rheumatoid arthritis and immune system disorders, such as glucocorticoids produce osteoporosis as a side effect in 50% of the population. It was found that xanthohumol in hops extract can significantly promote the expression of osteocalcin BGP, protein BMP-2, and bone-specific transcription factor Runx-2 in osteoblasts, further confirming that it can counteract the effects of drugs on osteoporosis by promoting bone formation in osteoblasts.

Antiviral

Xanthohumol (Xn) is the major isopentenyl chalcone analog in the female inflorescences of hops (Humulus lupulus), and it is currently found to be present only in hops, where it constitutes about 0.1% to 1% of the dry weight of hops. A growing number of studies have identified immunomodulatory and anti-inflammatory activities of Xn. Xanthohumol can inhibit pro-inflammatory pathways such as IL-1β, IL-6, IL-8, IL-12p70, TNFα and interferon γ by inhibiting farnesoid X receptor (FXR) activity and NF-κ b-dependent inhibition of pro-inflammatory genes expression. Experimental studies have demonstrated that Xn has a potent effect on many DNA and RNA viruses such as herpes simplex viruses type 1 and 2, cytomegalovirus, and the porcine reproductive and respiratory syndrome virus (PRRSV).

Applications:

For Health Products:

Hops have a long history of health applications. Hops extracts have been found to have a calming and tranquilizing effect on sleep, and some studies have demonstrated that hops can inhibit the Hepatitis C virus. Therefore, hops extracts are often used as additives in health products.

In the Food Field:

Hops extract can be used in beer brewing to give beer a pure, soft bitter flavor and hop aroma. It also acts as a preservative.

In Cosmetics:

Humulones in hops extract calm the blood vessels on the surface of the skin and reduce heat and inflammation. This is beneficial for repairing redness and marks on acne and acne-prone skin and is also restorative for rosacea. Hops extract is also used as a cosmetic ingredient.