Feverfew Extract 1% Parthenolide

What is Feverfew Extract Parthenolide?

Feverfew Extract is the flower bud extract of Chryanthemum Parthenium, a plant of the Tanace-tum in the family Asteraceae. It mainly contains sesquiterpene lactone, volatile oil (α-pinene), sesquiterpenes (camphor), flavonoids, and other components, the active ingredient is parthenolide. It has analgesic, anti-tumor, anti-fungal, anti-bacterial, and migraine pharmacological effects. It is commonly used in the treatment of migraine and is also used in the treatment of arthritis, rheumatic pain, dysmenorrhoea, and leukaemia.

Parthenolide is a naturally occurring sesquiterpene lactone from chamomile (Tanacetum parthenium) containing an α-methylene-γ-butyrolactone moiety and an epoxide moiety. It exhibits strong inhibitory effects on nuclear transcription factor κB (NF-κB)- and signal transduction and transcription (STAT)-inhibition-mediated pro-apoptotic genes. Parthenolide  has been reported to inhibit a variety of cancers, such as myeloma, colorectal, breast, cervical and prostate cancers.

Green Spring Technology supplies Feverfew Extract 1% Parthenolide is a fine brown powder extracted from natural Tanacetum Parthenium flower buds by supercritical carbon dioxide. It effectively maintains the activity and stability of parthenolide and improves the extraction efficiency. No organic solvent is added in the whole process to ensure the green safety of the extract.

Established in 2000, Green Spring is a leading biotechnology company in China, which has been committed to researching and supplying high quality plant extracts. Green Spring has a systematic quality management system, which is strictly implemented and production is organized under ISO, HACCP and other quality standards. A perfect traceability system has been established and all products are traceable. Green Spring has obtained many certifications such as Halal, Kosher, COSMOS, BRC, IFS, FDA, ISO, and so on. Authoritative third-party test reports are available. 

Specification: 

Regulation:

It conforms to EU regulations.

Benefits:

Anti-inflammatory

Modern scientific research has found that feverfew extract contains parthenolide, an ingredient with strong anti-inflammatory properties. It can quickly penetrate the skin, eliminating skin inflammation and relieving symptoms such as redness, swelling, and itching, bringing relief to people with sensitive skin.

Bacteriostatic

The volatile oil of feverfew extract has a certain inhibitory effect on Staphylococcus aureus, Staphylococcus albicans Proteus mirabilis, Streptococcus b haemolyticus and Diplococcus pneumoniae, and the inhibitory effect on Staphylococcus aureus is particularly obvious.

Beneficial for Migraine Treatment

Feverfew extract can improve migraine headaches is due to its ability to inhibit the production of serotonin in the brain. Serotonin causes blood vessels to tighten and release pain-causing chemicals. A clinical trial in the UK showed that consuming feverfew extract for four months significantly reduced the frequency and severity of migraine attacks. Also, Tanacetum Parthenium can help improve the nausea, vomiting, and visual disturbances that accompany migraines.

Inhibition of Hepatocellular Carcinoma Cells

Parthenolide can inhibit the proliferation of human hepatocellular carcinoma BEL-7402 cells and induce their apoptosis, one of the mechanisms may be related to the enhancement of p53 protein expression and inhibition of the expression of proliferating cell nuclear antigen protein, which inhibits the proliferation of cell nuclear antigen is involved in the synthesis of DNA; recent studies have shown that parthenolide belongs to the inhibitor of the nuclear factor Chemicalbook κB, and can induce apoptosis of many kinds of tumor cells.

It can induce apoptosis in a variety of tumor cells. The mechanism of enhancement is related to the fact that parthenolide can inhibit the activity of nuclear factor κB and enhance the apoptosis induced by 4-HPR in hepatocellular carcinoma cells, and the mechanism of enhancement is related to the fact that parthenolide can inhibit the activity of nuclear factor κB and enhance the apoptosis induced by 4-HPR in hepatocellular carcinoma cells.

Improves Rheumatoid Arthritis

Several laboratory studies have shown that feverfew extract can reduce inflammatory symptoms by slowing down the production of leukotrienes and arachidonic acid, compounds that cause inflammation. Clinical studies have reported a significant reduction in the frequency of arthritic flare-ups and pain levels in most people after taking feverfew extract for 2-3 months.

Applications:

In Cosmetics:

Feverfew extract is mainly used in cosmetics and skin care products as an anti-inflammatory agent, antioxidant, soothing and anti-allergic. It contains volatile oil, flavonoids, amino acids, chlorogenic acid, and trace elements. Based on the biological activities of chrysanthemum extract as antibacterial, antioxidant, anti-inflammatory, soothing, and anti-allergic, feverfew extract is widely used in cosmetics to prevent allergies, moisturize the skin, combat acne, and anti-aging.

It penetrates deep into the skin's underlying layers, repairing the damaged skin barrier, strengthening the skin's resistance and gradually restoring it to health. Feverfew extract also regulates the skin's water-oil balance, keeping the skin fresh and comfortable. It effectively inhibits allergens and reduces the occurrence of skin allergies. As a natural cosmetic ingredient, chamomile extract extract has been used in a variety of cosmetic products.

For Health Products:

Feverfew extract mainly contains sesquiterpene lactones, flavonoids and other components, the above ground part of feverfew is parthenolide, mukulene lactone and so on. A large number of studies have confirmed that feverfew extract parthenolide has anti-inflammatory, anti-tumour, migraine and other effects. Feverfew extracts have been used as raw materials for health products.