Naringin Powder

What is Naringin Powder?

Naringin, also known as Naringin, Citrin, and Isohesperidin, is a dihydroflavonoid isolated from grapefruit peel and has a bitter taste. It occurs naturally in the rind and pulp of grapefruit, tangerine, and orange in the Brassicaceae family. Naringin is one of the main active ingredients in traditional Chinese medicines such as Boneset, Citrus aurantium, Citrus aurantium, Citrus aurantium, and Citrus aurantium. The content of naringin in various plants varies greatly with species and origin, and usually, the content of naringin is higher in immature fruits. Modern pharmacological studies have found that naringin has anti-osteoporosis, antioxidant, anti-inflammatory, antibacterial, improves myocardial and liver damage, prevention and treatment of diabetes mellitus and complications.

The natural naringin powder provided by Green Spring Technology is extracted from the fruit of the Rutaceae plant Citrus grandis (L.) Osbeck. This naringin powder product is controllable and traceable from raw materials to finished products, with strict monitoring of pesticide residues in raw materials. The detection of various pollutants meets global standards. We can provide various contents of naringin powder, up to 98%. The quality is stable and has passed multiple quality certifications.

Specification: 

Regulation:

It conforms to EU regulations.

Benefits:

Preventing Osteoporosis

Studies have shown that naringenin has significant advantages in the treatment of osteoporotic bone damage and has the effect of preventing osteoporosis, promoting fracture healing, and repairing cartilage damage. Naringin can increase the expression of osteoblast marker proteins [such as osteocalcin, osteoblastin, osteoprotegerin, and bone formation protein-2 (BMP-2)], and also inhibit RANKL [The receptor activator of nuclear factor-kappa B (NF-κB) ligand (RANKL)]-induced NF-κB and ERK signaling. κB and ERK signaling activity and protein expression of osteoclast genes, which leads to the inability of osteoclasts to form normally, and therefore, serves to delay osteoporosis and promote the proliferation and differentiation of osteoblasts.

Antioxidant

Naringin has significant antioxidant and ameliorative effects on oxidative damage and has some pharmacological value to be developed as a natural antioxidant. The main mechanism of antioxidants is related to the scavenging of free radicals such as DPPH, AAPH, and ABTS by naringin, antagonizing their attack on cells, inhibiting the generation of ROS, and blocking the oxidative reaction of the body; regulating the content of various oxidative enzymes in the body, such as SOD, GSH, GST, MDA, MPO and so on, and repairing the damage caused by the oxidative stress of the body.

Naringin has a hydroxyl group in its molecular structure, which can react with harmful free radicals to become more stable semiquinone radicals to play an antioxidant role. By comparing the scavenging ability of naringin and ascorbic acid on 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals, it was found that naringin has a better scavenging effect on DPPH free radicals.

Antibacterial and Anti-Inflammatory

Studies have shown that naringin has a good anti-inflammatory effect, can improve the endotoxin lipopolysaccharide (LPS)-induced inflammatory injury, has the ability to inhibit the protein and gene expression levels of interleukin-6 (interleukin-6, IL-6), IL-8, IL-1β in the inflammation model, and reduces the concentration of leukotriene B4 (leukotriene B4, LTB4) and tumor necrosis factor-α (TNF-α). leukotriene B4 (LTB4) and tumor necrosis factor-α (TNF-α) concentrations. Meanwhile, it was also found that the inhibitory effect of naringin combined with filaggrin on inflammatory factors was significantly stronger than that of naringin or filaggrin alone, indicating that the combination of naringin is of great significance in improving the clinical efficacy, improving the body's tolerance to the drug, and exerting the best anti-inflammatory efficacy.

Improvement of Myocardial and Hepatic Injury

Naringin has an ameliorative effect on common in vivo and in vitro experimental myocardial injuries. The mechanism is related to the fact that naringin regulates the expression of apoptotic factors, inhibits myocardial tissue protein phosphorylation, and blocks the activation of the inflammatory pathway NF-κB after myocardial ischemia/reperfusion injury (MI/RI) and hypoxia/reoxygenation injury (H/R).

Naringin is effective in the study of preventing and treating experimental liver injury, and has certain pharmacological effects. The mechanism is related to the fact that naringin can significantly reduce CYP450 activity, inhibit I-phase enzyme metabolism, promote II-phase enzyme metabolism, and eliminate the damage of exogenous substances on hepatocytes; it is also related to the regulation of a variety of intracellular oxidative enzymes, inhibition of oxidative damage, apoptosis of hepatocytes, and further repair of damaged hepatocytes.

Applications:

In the Food Field:

Naringenin powder can be used as naringenin both a natural color, flavor modifier and bittering agent in the production of food and beverages. It can also be used as a raw material for the synthesis of sweetness, non-toxic, low-energy new sweetener dihydronaringenin chalcone and neohesperidin chalcone.

In Cosmetics:

The main role of naringin in cosmetics and skin care products is as a skin conditioning agent.

In Pharmaceutical:

Naringin has anti-inflammatory, anti-viral, anti-cancer, anti-mutagenic, anti-allergic, anti-ulcer, analgesic, blood pressure lowering activity, can lower blood cholesterol, reduce the formation of thrombus, improve the local microcirculation and nutrient supply. The Naringin powder can be used in the production of the prevention and treatment of cardiovascular and cerebrovascular diseases.