Silymarin Powder Milk Thistle Seed Extract

What is Silymarin Powder?

Silymarin, also known as milk thistle seed extract, is a flavonoid lignan-like compound extracted from the seed coat of milk thistle seeds. It is a yellow or brown powder with a bitter taste. Soluble in acetone, ethyl acetate, ethanol, and methanol, insoluble in chloroform, and insoluble in water. Silymarin is a flavonoid with a healing effect for liver disease found in the world, with the protection of the liver, improves liver function. It prevents the damage of external factors to the liver, promotes the regeneration and repair of liver cells, as well as anti-radiation and slow aging effects.

Green Spring Technology supplies Silymarin Powder in bulk in UV80%, HPLC45% , HPLC60%, Silybin & Isosilybin 30%, Silybin 30%, Silybin 35%, and Water Soluble Silymarin. The raw material of silymarin is selected from organic silymarin plantations. A strict control system is established, with "0 additives" and "0 pollution" in the planting and harvesting process.

 Adopting original technology design, effective degreasing and residue removal to meet the quality requirements of high-end customers. Green Spring has industry-leading technical capabilities and professional technical personnel, R & D testing centre and perfect testing equipment, product testing implementation of the European Pharmacopoeia, the U.S. Pharmacopoeia, the Japanese Pharmacopoeia, pesticide residues, solvent residues, heavy metals are in line with international standards. We can provide authoritative third-party test reports.

Specification:

Regulations:

It conforms to EU regulations.

Benefits:

Liver Protection

Silymarin has a long history of use in clinical applications for the treatment of liver disease. Silymarin is often used as a liver-protecting drug and has achieved good efficacy. It is mainly used in the treatment of toxic and alcohol-related liver diseases. Silymarin powder is a natural medicine with excellent effects against liver and biliary diseases. It can remove free radicals damaging liver cells, form a protective film on liver cells, and repair damaged liver cells.

Lipid Lowering

Silymarin inhibits Ca2+ channels in the plasma membrane of adult rat cardiomyocytes, inhibits food-induced hypercholesterolemia, lowers very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL), and raises high-density lipoprotein (HDL), and can be used in the treatment of cardiovascular system diseases.

Anti-Inflammatory

By inhibiting the phosphorylation and degradation of IκB, silymarin can inhibit the activation of NF-κB, regulate the expression of genes related to inflammation, cell survival, cell differentiation, and cell growth, and exert anti-inflammatory effects.

Anti-UVA Damage

Silymarin application widely reduces the depletion of glutathione (GSH), the most important antioxidant in UVA-irradiated cells. Reduces UVA-induced ROS production, membrane lipid peroxidation, and cysteine asparaginase (Caspase-3) activation and DNA single strand breaks (SSB), DNA damage. It is beneficial in the treatment of UVA-induced oxidative skin damage and inflammation. It was further shown that silymarin reduced multiple ROS levels both in vitro and ex vivo, and reduced UVA damage to the membrane integrity of keratinocyte-forming cells. In particular, silymarin effectively eliminated UVA-induced DNA single-strand breaks at levels close to those of unirradiated cells.

Antioxidant, Slowing down Skin Aging

Silymarin is a polyphenol flavonoid antioxidant with strong antioxidant effects. It can upregulate the skin's antioxidant defense system, and scavenge ROS and oxygen free radicals. It also slows down the aging of vascular endothelial cells by increasing telomerase activity 3-fold and reducing the number of senescent cells. In the Drosophila stress test, the survival rate of Drosophila with a high purity mass fraction of 95% silymarin was approximately 3 times higher.

Whitening

Silymarin has been found to have a good chelating effect on trivalent iron ions, so it is inferred that its inhibition of tyrosinase is also achieved by chelating copper ions. This suggests that the glucosamine salt complex of silymarin powder is suitable for use as a safe and efficient whitening additive in a wide range of whitening cosmetics.

Lipid-lowering

Experiments in mice have confirmed that silymarin reduces triglyceride (TG) content in the liver and serum TG and total cholesterol (TCh) levels. Moreover, these animal experiments also showed that aspects of liver pathology (e.g., steatosis, inflammation, and hepatocyte ballooning) improved to varying degrees after silymarin application interventions. It has also been suggested that the drug reduces the body weight of the subject animals.

Antioxidant

Reactive oxygen species (ROS) are highly reactive and can interact with unsaturated fatty acids to trigger lipid peroxidation, damage cell membranes, and cause chromosomal aberrations. Silymarin was found to significantly inhibit ROS production by human neutrophils in a dose-related manner.

Applications:

For Health Product:

Silymarin, a silymarin seed extract, plays an important role in liver protection by stimulating the formation of new liver cells, preventing cytotoxic infiltration of liver cells, and improving the self-repairing ability of liver cells. In addition, silymarin extract has excellent antioxidant and hypolipidemic properties. Silymarin powder can be widely used in the treatment and prevention of fatty liver, hepatitis, cirrhosis, cardiovascular and other diseases, and has great potential for development in the field of medicine and health care products.