Loquat Leaf Extract Corosolic Acid Powder 10%

What is Loquat Leaf Extract Corosolic Acid Powder?

Loquat Leaf Extract Corosolic Acid Powder refers to the effective active ingredient Corosolic Acid powder extracted from the dried stem and leaves of Loquat (Eribotrya japonica (Thunb) Lindl), family Rosaceae. The results of in vitro and in vivo experiments show that corosolic acid promotes the absorption and utilisation of glucose by cells through the excitation of glucose transport, thus achieving its hypoglycemic effect. The excitatory effect of Corosolic acid on glucose transport is similar to that of insulin, therefore, Corosolic acid is also known as plant insulin.

Corosolic acid can exist freely in plants or in the form of saponins. In plants, it often co-exists with its isomer hawthorn acid (2α-hydroxyoleanolic acid), which is structurally and chemically similar and difficult to separate.

The Loquat Leaf Extract Corosolic Acid Powder 10% supplied by Green Spring Technology is a kind of effective plant active ingredient that is produced by extracting, crystallizing, and drying the leaves of Loquat Leaf of high quality, with high purity, no pesticide residue, low solvent residue and has been used as the raw material of health care products.

Green Spring has always been committed to providing customers with natural, safe, and organic plant extracts. We organize our production in accordance with ISO, HACCP, and other quality standards. A perfect traceability system has been established, all products are traceable, and each product from source to finished product has detailed testing, and production reports, to ensure that every link in the production process is controllable and traceable. We have passed Halal, Kosher, COSMOS, BRC, IFS, FDA, ISO, and many other certifications. We can provide authoritative third-party test reports.

Specification:

Regulations:

It conforms to EU regulations.

Benefits:

Hypoglycaemic

Loquat Leaf Extract Corosolic Acid Powder has the ability to lower blood glucose, regulate lipid metabolism, and improve diabetes. Corosolic acid can reverse the pathological process of diabetes mellitus by regulating the metabolic interference pathway; it can enhance the cellular uptake of glucose, impair the hydrolysis of sucrose and starch, and reduce the regulation of glucose and lipid metabolism; and lower blood glucose by the inhibitory effect of α-glucosidase, and so on.

Corosolic acid has a completely new pathway when it comes to cellular glucose transport proteins, which absorb glucose into the body's muscles and control blood sugar levels. In addition, corosolic acid inhibits the body's mechanism for making glucose in a process called gluconeogenesis. This mechanism works better to lower blood sugar levels in the body.

Antioxidant

Loquat leaf extract Corosolic acid effectively inhibited Cu2+-induced oxidation of human low-density lipoprotein (LDL) in vitro, protected aortic endothelial cells (HAECs) from AAPH-induced oxidative damage by free radicals, and preserved the integrity of cellular structure. The mechanism is likely to be achieved by increasing antioxidant enzymes such as SOD and glutathione peroxidase (GSH-PX) in the cells.

Anti-inflammatory

In a lipopolysaccharide-induced inflammation model constructed in RAW264.7 cells, loquat leaf extract inhibited the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2), and its anti-inflammatory effects were associated with the down-regulation of NF-κB and extracellular-regulated protein kinases (ERKs), p38 mitogen-activated protein kinases (p38 MAPKs), and stress-activated protein kinases (JNKs) protein expressions. ) protein expression is associated. Corosolic acid in loquat leaves plays a role in the treatment of chronic bronchitis (CB) by inhibiting lipopolysaccharide (LPS)-induced IL-8 production and NF-κB activation, and inhibiting i NOS mRNA expression.

Hepatoprotective

Loquat leaf extract ursolic acid powder inhibited the proliferation of HSC-T6 cells cultured in vitro and decreased ECM secretion. Its mechanism of action may be related to the up-regulation of peroxisome proliferator-activated receptor-γ (PPAR-γ) gene and protein expression, and the down-regulation of TGF-β1 gene and protein expression of loquat leaf ursolic acid; loquat leaf ursolic acid exerts hepatoprotective and anti-hepatocellular fibrotic effects by inhibiting hepatic stellate cell activation.

Applications:

For Health Products:

Corosolic acid powder, as a new plant drug against obesity and type II diabetes and functional natural health food pharmaceutical raw materials, has become a popular product in the market; the natural product has been listed as a nutritional supplement in the United States, while conducting phase III clinical trials for the treatment of diabetes, and will be certified by the FDA in the near future. Its effect for the treatment of diabetes mellitus is comparable to that of insulin injection, with the advantages of significant oral effect, small toxic side effects, easy of use, etc. The effect is comparable to that of insulin injection.