Diosgenin Powder

What Is Diosgenin?

Diosgenin, commonly known as diosgenin, is a kind of steroid diosgenin naturally synthesized by plants and widely exists in the tubers of leguminous and Dioscoreaceae plants. It is an important raw material for the synthesis of Steroid hormone drugs. It has many remarkable pharmacological effects, such as anti-tumor, anti-inflammatory, antioxidant, and has high medicinal value.

Green Spring provides diosgenin powder extracted from wild yam tubers. It is a natural DHEA (dehydroepiandrosterone), which can promote the metabolism of skin epidermal cells, enhance the moisturizing function of skin, and also help improve the physique.

Specification: 

Regulation:

It conforms to EU regulations.

Benefits:

Antitumor Activity

In vivo and in vitro studies have shown that diosgenin has cytotoxicity to a variety of tumor cells, including breast cancer cells, colon cancer cells, prostate cancer cells, lung cancer cells, gastric cancer cells, Osteosarcoma cells, etc. It can play an anti-tumor role by inhibiting tumor cell proliferation, inducing tumor cell apoptosis, blocking cell cycle, and anti-tumor metastasis.

Hepatoprotective Effect

Diosgenin powder can effectively inhibit the cell viability of HSC-T6, LX-2, and primary rat hepatic stellate cells (HSCs), while liver cells are not affected. Diosgenin also has a good protective effect on alcoholic liver injury, which is achieved by reducing oxidative stress, the production of inflammatory cytokines, cell apoptosis, and liver steatosis.

Hypoglycemic Effect

The combination of NPH insulin and diosgenin in the treatment of elderly type 2 diabetes is more effective in reducing blood sugar with good safety, which may be related to the reduction of Glycated hemoglobin formation.

Anti Osteoporosis Effect

Dioscin can promote the proliferation of osteoblasts and inhibit the formation of Osteoclast. Research has shown that after diosgenin treatment of MC3T3-E1 cells, ER- α、 ER- β、 Lrp5 β- The expression of both catenin and Bcl-2 proteins increased, and the ratio of OPG/RANKL increased, depending on the LRP5 pathway, thereby promoting osteoblast proliferation.

Applications:

Pharmaceutical Intermediate:

Diosgenin powder is an important steroidal saponin and an important raw material for Semisynthesis steroidal compounds.