D Mannose Powder Bulk

What is D Mannose Powder Bulk?

D Mannose powder is a monosaccharide. It is an isomer of glucose and enters cells via glucose transport proteins. Mannose is catalyzed intracellularly by hexokinase to produce mannose-6-phosphate (M6P), which can be catalyzed by phosphomannose isomerase (PMI) to enter the glycolytic pathway or by phosphomannose mutase (PMM2) to enter the glycosylation pathway.

D mannose is present in a free state in the peel of certain plants, such as in citrus peel, small amounts of free mannose in fruits such as peaches and apples, and glycans containing D-mannose in ivory palm seeds, yeast, red algae, serum globulin, egg-like mucin, and Mycobacterium tuberculosis.

Green Spring Technologies produces D Mannose Powder Bulk with high purity, low endotoxin content, low colony counts, and low heavy metals. It is tested for heavy metals as specified in ICH Q3D at concentrations as low as parts per billion (ppb).

Green Spring has an excellent R&D team, an experienced production team, and a professional sales team. We have a systematic quality management system and organize production in strict accordance with ISO, HACCP, and other quality standards. We have passed Halal, Kosher, COSMOS, BRC, IFS, FDA, ISO, and many other certifications. We can provide authoritative third-party test reports.

Specification: 

Regulations:

It conforms to EU regulations.

Benefits:

Inhibiting Tumour Growth

A study reported in Nature 2018 found that D mannose powder can inhibit tumour growth by suppressing glucose metabolism by screening the effects of different hexoses on the growth of tumour cell lines. Lui Lei's team sought to explore whether various hexoses affect tumour immunity. Through screening, the researchers found that high concentrations of D-mannose were able to degrade PD-L1 protein in TNBC cells. In-depth mechanistic studies revealed that D-mannose treatment could promote the activation of AMPK, which promoted the phosphorylation of the S195 site of PD-L1 protein. The phosphorylation of this site can weaken the glycosylation of PD-L1 protein, which leads to the degradation of PD-L1 protein through proteasome.

Further studies revealed that D-mannose-mediated degradation of PD-L1 also inhibited the DNA damage repair process in tumour cells, resulting in a facilitating effect on radiotherapy for TNBC. In a mouse model of TNBC, the combination of oral D mannose and PD-1 antibody treatment significantly prolonged the survival of hormonal mice and increased CD8+ T cell infiltration and granzyme B expression in the tumour. Similarly, the combination of oral D-mannose and ionising radiation significantly inhibited tumour growth in vivo and significantly enhanced the efficacy of radiotherapy in TNBC mice.

In conclusion, this study revealed a new function of D-mannose - degradation of PD-L1 protein and reported for the first time the facilitating effect of D-mannose on immunotherapy and radiotherapy of TNBC, which provides a new strategy for the clinical treatment of TNBC.

Cell Recognition

D Mannose powder is one of the important components of cell surface glycosylation that can participate in cell recognition and interaction with the external environment.

Immunomodulation

D Mannose plays an important role in the immune system and is involved in intercellular signaling, inflammatory regulation, and activation of immune cells.

Antiviral

D mannose powder can interact with certain viral structural proteins to inhibit viral invasion and replication processes.

Applications:

For Feed Product：

Overuse of antibiotics in farming leads to the proliferation of resistant bacteria as well as pollution of the environment. Studies have demonstrated that D mannose powder can inhibit the infection of Salmonella in young chickens without side effects. Adding D mannose powder to livestock and poultry feed has the effect of inhibiting the proliferation of pathogens in the intestinal tract, protecting the health of animal intestinal tract, increasing immunity and disease resistance, and improving feed utilization.

For Health Products:

D Mannose powder has been used clinically as a glyconutrient. It can be widely distributed in body fluids and tissues, especially in the nerves, skin, testes, retina, liver, and intestine. The body can directly use mannose to synthesize glycoproteins and participate in immune regulation. In recent years, a series of surprising physiological activities of mannose, a common monosaccharide, have been revealed, including anti-inflammation, inhibition of bacterial infections, alleviation of diabetes, anti-tumor, etc. D mannose powder has been used as an additive in nutraceuticals.