Alpha Lipoic Acid Bulk Powder

What is Alpha Lipoic Acid?

Lipoic acid was isolated from pig liver in 1950 by American scholars Reed and others, and today it can be obtained by synthetic methods. Lipoic acid is an essential nutrient. The human body is also able to synthesize some of its own lipoic acid from fatty acids and cysteine, but this is far from enough to satisfy the need, and the body's ability to synthesize lipoic acid decreases with age, so it needs to be supplemented through food. The highest content of lipoic acid in plants is spinach, followed by broccoli and tomatoes, and the highest content in animals is found in animal kidneys and livers.

Alpha lipoic acid has been found to have powerful antioxidant properties and is the only substance known to exert antioxidant capacity in both fat-soluble and water-soluble environments. Lipoic acid can play a powerful anti-oxidative stress role in the body through the direct scavenging of reactive oxygen radicals, chelating with free metal ions, and promoting the regeneration of endogenous antioxidants, oxidative stress is the pathological basis of a variety of diseases, such as diabetes, cardiovascular disease, liver disease, and tumors, etc., so that alpha lipoic acid can play a preventive and therapeutic role in a variety of clinical systemic diseases.

Green Spring Technology supplies food grade Alpha Lipoic Acid Bulk Powder, with low pesticide residue, and no solvent residue. Strictly comply with international standards such as European Pharmacopoeia, U.S. Pharmacopoeia, Japanese Pharmacopoeia and so on. Authoritative third-party test reports are available.

Specification:

Regulations:

It conforms to EU regulations.

Benefits:

Neuroprotective Effects

Free radical-induced injury is an important component of secondary neuronal brain damage in stroke treatment, and there is no effective treatment to prevent this effect. Alpha Lipoic Acid’s antioxidant properties have been linked to its neurorestorative and neuroprotective effects. Alpha lipoic acid administered via the jugular vein reduces mortality, neurological deficit scores, and infarctions, and increases neurogenesis and cerebral cellular metabolism, resulting in a neuroprotective effect. effects. α-Lipoic acid induces microglia M2 phenotype, regulates the expression of pro-inflammatory cytokines IL-6, IL-1, IL-10, and tumor necrosis factor (TNF), and inhibits transcription factor NF-κB, a key mediator of an inflammatory response (Wang et al., 2018).

Beneficial for Neurodegeneration

In Parkinson's disease, MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a neurotoxin that causes loss of dopaminergic cells in a mouse model (Langston 1985). This novel toxin triggers the death signaling pathway through activation of mouse substantia nigra compacta (SNpc) apoptosis signal-regulated kinase 1 (ASK1) and translocated death structural domain-associated protein (DAXX); alpha lipoic acid terminates this cascade of responses and provides neuroprotection (Karuna-karan et al. 2007). Oxidative stress is responsible for the degeneration of dopaminergic neurons in Parkinson's disease patients, and α-lipoic acid mediates the inhibition of the p53 protein, which increases the expression level of nuclear antigens in proliferating cells (Li et al. 2016).

Several studies have found that alpha-lipoic acid in combination with omega-3 fatty acids has a synergistic effect on slowing functional and cognitive decline in Alzheimer's disease (Shinto et al. 2014). In scopolamine-induced memory loss, alpha lipoic acid inhibits brain weight loss, down-regulates oxidative tissue damage leading to neuronal cell loss, repairs memory, and motor function, reduces proliferation of reactive astrocytes, and reduces chromatin lysis in cerebellar-hippocampal cortex (Bastianetto and Quirion 2004).

Beneficial for Cardiovascular Disease

Dihydrolipoic acid has been reported to have properties that regulate blood lipids, prevent oxidation of low-density lipoproteins, and regulate hypertension, suggesting that alpha lipoic acid may be a possible protective agent against cardiovascular disease (Wollin and Jones 2003). As alpha-lipoic acid intake increased, the incidence of cardiovascular disease decreased.

Beneficial for Kidney-Related Diseases

Alpha-lipoic acid taken with antioxidants such as alpha-tocopherol or vitamin E and N-acetylcysteine can help dialysis patients with elevated oxidative stress (Lim et al. 1999; Nazrul et al. 2000; Roob et al. 2000; Leehey et al. 2005). alpha-lipoic acid has better antioxidant activity than N-acetylcysteine against oxidative stress, including diabetic neuropathy and glomerular damage. glomerular injury.

The antioxidant activity of alpha lipoic acid is superior to that of N-acetylcysteine.α-Lipoic acid leads to a decrease in markers of oxidative stress (LDL oxidative and plasma protein carbonyls); therefore, it is noteworthy that administration of this drug reduces oxidative stress induced by intravenous iron (Marangon et al., 1999). However, in diabetic nephropathy, TGF- β1 is associated with MAPK and induces the production of connexin in tethered cells. Alpha lipoic acid ameliorates proteinuria by reducing the expression of TGFβ1 and connexin (Lee et al., 2009). Patients with autosomal dominant polycystic kidney disease treated with α-lipoic acid showed significant improvements in metabolism, inflammation, and endothelial function (Lai et al. 2020).

Beneficial for Inflammatory Lesions

Alpha lipoic acid is a short-chain fatty acid that is synthesized in the body and acts as an antioxidant, protecting the body's cells from damage and helping to restore the scale of other antioxidants such as vitamins C and E (Moura et al. 2021). Several studies have shown that α-lipoic acid in combination with fructose can reduce fructose-induced inflammation, hepatic oxidative stress, and insulin resistance.

Studies have also found that alpha-lipoic acid can act as a chemopreventive agent as it inhibits inflammation associated with carcinogenesis (Moon 2016). Alpha-lipoic acid powder reduces markers of inflammation in patients with heart disease as oxidative stress is thought to be a major cause of many cardiovascular diseases, including hypertension and heart failure. Oxidative stress is increased during the aging process, leading to enhanced ROS production or reduced antioxidant safeguards. The incidence of heart disease is directly related to a person's age.

Applications:

For Health Product:

As a dietary supplement, alpha lipoic acid powder has become a common ingredient in conventional products such as anti-aging supplements and multivitamin preparations. alpha-lipoic acid is increasingly used in dietary supplements due to its antioxidant and anti-diabetic properties. At the same time, it improves aging-related cognition, diabetes, cardiovascular and erectile dysfunction, neuromuscular loss, and cancer.