50% Natural Fisetin Powder Bulk

What is Natural Fisetin Powder Bulk?

Fisetin (3,3',4',7-tetrahydroxyflavone, yellow needle crystal, molecular formula C15H10O6, molecular weight 286.23), with a density of 1.688g/ml and a melting point of 330 ° C. It has four hydroxyl groups in the molecule, soluble in ethanol, acetone and acetic acid, and almost insoluble in water, ether, benzene, chloroform and petroleum ether. Modern research has shown that fisetin has a wide range of pharmacological activities, with important roles in improving cognition, antioxidant, osteoporosis prevention, antidepressant, neuroprotective, antithrombotic, anti-inflammatory, antitumour and hypoglycaemic.

Natural fisetin powder is a natural flavonoid compound extracted from plants such as Mullein, a member of the lac family. It has antioxidant, anti-inflammatory, anti-tumor and anti-aging properties.

Green Spring Technology supplies 50% Natural Fisetin Powder Bulk, which comes from high quality Cotinus Coggygria stems. It has no pesticide residue, no solvent residue, and heavy metals in accordance with international standards such as European Pharmacopoeia, US Pharmacopoeia, and Japanese Pharmacopoeia. Green Spring has passed Halal, Kosher, COSMOS, BRC, IFS, FDA, ISO and many other certifications. We have a systematic quality management system, strictly implement the quality management system, and organise production according to ISO, HACCP and other quality standards. We can provide authoritative third-party testing reports.

Specification:

Regulations:

It conforms to EU regulations.

Benefits:

Antioxidant and Anti-Inflammatory

As a flavonoid with inherent antioxidant properties, natural fisetin powder has direct antioxidant activity and increases glutathione, the main intracellular antioxidant. Even in the presence of oxidative stress, fisetin maintains mitochondrial function so well that even the very fragile neuronal cells are well protected.

In addition to its antioxidant talent, its anti-inflammatory effect should not be underestimated. Fisetin inhibits the NF-κB pro-inflammatory signaling pathway by activating β-catenin protein and silencing the expression of TLR4, which in turn down-regulates the release of inflammatory cytokines and achieves anti-inflammatory effects.

Anti-tumour

In the early stages of a tumour, fisetin can interfere with chromosome segregation and promote DNA double-strand breaks, thus reducing its proliferation rate. In the rapid growth phase of tumours, Fisetin also reduces angiogenesis by inhibiting uPA (urokinase fibrinogen activator), cutting off the source of nutrients to the tumour. In the advanced stage of tumours, tumours may metastasize, and fisetin powder can prevent the degradation of the ECM protein barrier by inhibiting the key target of MMP-1, thus preventing the entry of tumour cells into the bloodstream and inhibiting the metastasis of tumour cells.

Anti-Aging

It was in 2007 when Sinclair et al discovered that Fisetin could activate the SIRT1 longevity protein that Fisetin came to prominence in the anti-aging world. Following the concept of Senolytics introduced by Dr James Kirkland in 2015, Fisetin has become a popular Senolytics substance due to its powerful ability to remove senescent cells. Natural fisetin powder relies on two main things to exert its powerful anti-aging abilities, one as a calorie restriction mimetic and the other as a Senolytics substance. As a caloric restriction mimetic, fisetin induces autophagy by upregulating the expression of SIRT1 in the Sirtuins family, which in turn inhibits mTOR. Unlike other caloric restriction mimetics, Fisetin is tissue specific and more effective in promoting autophagy in brain cells.

Beneficial to Cardiovascular Health

Fisetin may help reduce the risk of cardiovascular disease by improving blood vessel function and lowering cholesterol levels.

Protecting the Nerves

Research has found that fisetin powder promotes healthy aging by reducing oxidative stress and increasing glutathione levels, which may help protect nerve cells and slow damage associated with neurodegenerative diseases such as Alzheimer's disease.

Applications:

For Health Products:

Studies have shown that fisetin can exert antidepressant effects by inhibiting the monoamine oxidase of 5-hydroxytryptamine ; it has significant protective and repairing effects on liver damage caused by hepatitis; and it can significantly improve immune cell activity. Natural fisetin powder has been used as an additive in health products.