Epimedium Extract Powder Icariin

What is Epimedium Extract Powder?

Epimedium extract powder refers to the dried stems and leaves of Epimedium brevicornum, etc. processed into powdered active ingredients. The main active ingredient of epimedium extract powder is flavonoids, including Icariin, Icariins, Epimedium hypoglycoside, Epimedium macrocephaloside C, Asahioglossus glycoside A, B, C, etc., and also contains saponins, bitterness, tannin, volatile oils, wax alcohols, trichothecenes, phytosterols, and chondrusitric acid, Oleic acid and so on. They have an androgen-like effect, used to improve immunity, antihypertensive, staphylococcus aureus, and poliovirus-induced infections have an obvious inhibitory effect. There are also cough suppressant, expectorant, and asthmatic effects. Epimedium Extract Powder is mainly used internationally as a raw material for health products to improve sexual function.

Green Spring Technology supplies Epimedium Extract Powder Icariin, the main active ingredient is Icariin, the content varies from 5%, 10%, 20%, 60%, 98%. It has stable properties, good solubility, low moisture content and can be stored for a longer period of time. Its pesticide residues, solvent residues and heavy metals meet the international standards of European Pharmacopoeia, Japanese Pharmacopoeia and American Pharmacopoeia.

Green Spring is a leading supplier of botanical extracts in China, which was established in 2000 and specializes in providing customers with natural, safe, and organic botanical extracts. Greenspring organizes its production by ISO, HACCP, and other quality standards. We have a rigorous internal quality control process to ensure that our products meet international standards. We have passed Halal, Kosher, COSMOS, BRC, IFS, FDA, ISO, and many other certifications. Authoritative third-party test reports are available.

Specification: 

Regulation:

It conforms to EU regulations.

Benefits:

Promote Reproductive System

Epimedium Extract Powder Icariin, as one of the active ingredients of Horny Goat Weed, a key medicine for tonifying the kidney and aiding the yang, can promote the function of the reproductive system. Icariin can inhibit ferrous sulfate/hydrogen peroxide-induced oxidative stress damage in human spermatozoa, activate the ERK1 /2 signaling pathway, promote the proliferation of testicular trophoblast Sertoli's, and enhance male reproductive function.

Icariin also up-regulates cytochrome P450 17 and 19 levels, promotes aromatase expression, induces proliferation of ovarian granulosa cells, and increases estrogen and progesterone production. It can also increase the weight of ovaries, uterus, and pituitary glands, promote pubertal development in female rats, and prolong the duration of estrus in pubertal rats. In addition, Icariin can reduce the levels of follicle-stimulating hormone and luteinizing hormone, increase the level of estradiol, up-regulate the expression of ovarian anti-mullerian tubular hormone, increase the Bcl-2 /Bax ratio in the ovarian tissues, improve the development of ovarian follicles in aging mice, inhibit follicular atresia, and improve their fertility.

Beneficial for Neurological Disorders

Epimedium Extract Powder Icariin have been shown to be beneficial for a variety of neurological disorders such as cerebral ischemia, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and depression.

Icariin can increase the level of superoxide dismutase (SOD), reduce the expression of amyloid precursor protein and β-secretase, reduce the production and accumulation of Aβ, attenuate Aβ-mediated atrophy of axons and dendrites, and improve the spatial learning and memory ability of Alzheimer's disease model rats. Icariin can also inhibit the Aβ-induced hyperphosphorylation of serine 396, 404, and threonine 205 of tau protein, thus exerting a protective effect on nerve cells.

Icariin can inhibit NF-κB inhibitory protein α degradation and NF-κB activation, up-regulate peroxisome proliferators-activated receptors (PPARs) α and γ protein levels, and alleviate neuroinflammation. Icariin can also reduce the level of lactate dehydrogenase and malondialdehyde, weaken the activity of SOD, enhance the antioxidant ability, inhibit the increase of intracellular calcium concentration, and attenuate the neuronal damage of ischemia/reperfusion. In addition, Icariin can inhibit the activation of myelin-associated growth inhibitory factor, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein in the ischemic area, promote axon germination and regeneration, and improve nerve function.

Protecting the Skeletal System    

Epimedium Extract Powder Icariin can promote the formation and activation of osteoblasts and inhibit the formation and function of osteoclasts to alleviate osteoporosis. Icariin can activate ERα-Wnt/β-catenin and Notch signaling pathway, and up-regulate the expression of runt-related transcription factor 2, a key gene of osteoblasts, to play the role of osteogenesis. It can activate mitogen-activated protein kinase (MAPK) signaling pathway, increase the gene expression of type I collagen, osteocalcin, and osteopontin, enhance the self-renewal ability of bone mesenchymal stem cells (BMSCs) in vivo and in vitro, and induce BMSCs to develop into osteoblasts. BMSCs were induced to differentiate into osteoblasts, which in turn enhanced osteogenic differentiation. In addition, Icariin can promote the synthesis of estrogen and has an estrogen-like effect, which can activate extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), promote the proliferation of osteoblasts, activate BMP-2/Smad4, and activate BMP-2/Smad5, and activate BMP-2/Smad6, and activate BMP-2/Smad7. BMP-2/Smad4, and increased osteoblast viability.

Protection of the Cardiovascular System

Icariin can exert a protective effect on the cardiovascular system by protecting cardiomyocytes, promoting cardiomyocyte production, and improving endothelial dysfunction.

Epimedium Extract Icariin can block angiotensin II-induced cardiomyocyte hypertrophy and apoptosis by inhibiting the activation of JNK and p38 pathways and activating ERK to scavenge reactive oxygen species and inhibit oxidative stress in cardiomyocytes. Icariin can also activate PI3K/Akt/endothelial nitric oxide synthase (eNOS) signaling pathway, reduce the level of creatine kinase, ischemia-modified albumin and lactate dehydrogenase, reduce apoptotic cells, myocardial infarction area, and improve myocardial ischemia-reperfusion injury in rats; down-regulate the activities of matrix metalloproteinases 2 and 9, and improve myocardial cell hypertrophy and apoptosis. 9 activities, improved cardiomyocyte apoptosis, and attenuated left ventricular dysfunction and cardiac remodeling.

Epimedium Extract Icariin activates the p38MAPK pathway, increases the expression of peroxisome proliferator-activated receptor gamma coactivator-1α, PPARα, and nuclear respiratory factor 1, promotes the differentiation of embryonic stem cells to cardiomyocytes, and up-regulates the expression of specific myosin light chain-1v, atrial natriuretic peptide, cardiac troponin I, troponin, and sodium-calcium exchanger in differentiated cardiomyocytes, maintaining the normal functional structure of cardiomyocyte beating. In addition, Icariin can activate ERK-dependent signaling pathway and stimulate the differentiation of mouse adipose-derived stem cells into cardiomyocytes.

Regulating the Immune System

Epimedium Extract Icariin can improve the condition of autoimmune diseases such as rheumatoid arthritis, bronchial asthma, multiple sclerosis, and systemic lupus erythematosus, and is related to its regulation of lymphocyte function. Epimedium glycoside can inhibit the differentiation of helper T cells (Th) 1 and 17, and improve autoimmune encephalomyelitis in mice. Epimedium glycoside can inhibit the activation of STAT3 in T cells, downregulate the proportion of Th17 cells, inhibit the production of interleukin-17, and improve the symptoms of rheumatoid arthritis; Can regulate the proportion of Th1/Th2 cells in the lung tissue of asthmatic rats and the balance of Th17/regulatory T cells in asthmatic mice, improving asthma; It can enhance the activity of lymphokine activated killer cells and natural killer cells, and enhance the human immune system.

Applications:

For Health Products:

Icariin is the main component of epimedium extract flavonoid and also the main antioxidant active ingredient in Epimedium. Its chemical structure belongs to flavonoid compounds, which have various biological activities both in vivo and in vitro. It has a bidirectional regulatory effect on bone metabolism, including enhancing human immunity, anti-tumor and antioxidant properties, promoting tissue protein synthesis, promoting osteoblast growth, and inhibiting osteoclast activity. Epimedium extract icariin is often used as an additive in health products.

For Feed Product：

The test results showed that adding epimedium extract powder to feed promoted the development of the thymus, spleen, and bursa, improved the effect of vaccine for Newcastle disease and avian influenza, strengthened immunity, improved resistance to infectious diseases, and reduced the mortality rate as well as morbidity rate. Adding Epimedium Extract Powder Icariin to feed can prevent and control epidemic diarrhea in pigs. Rapidly regulate the intestinal physiological function of female animals and optimize the intestinal environment. Improve the reproductive ability of sows and promote the growth of animals.