Centella Asiatica Extract Madecassoside 90%

What is Centella Asiatica Extract Madecassoside?

Madecassoside is the active ingredient extracted from the plant Centella Asiatica. Centella asiatica is a fan-shaped plant with serrated edges in the umbelliferae family. The leaves and rhizomes of Centella Asiatica are rich in madecassoside, which has anti-inflammatory properties and is often used as an ingredient in products such as ointments, toothpastes, and skin care products. Madecassoside is also categorized as a triterpenoid that stimulates the production of type III collagen. In studies, madecassoside has shown skin healing and skin anti-aging properties. Genistein has been shown to have some anti-inflammatory properties in the treatment of psoriasis.

Green Spring Technology supplies Centella Asiatica Extract Madecassoside 90% with stable performance and high purity. It adopts the advanced liposome technology to wrap Madecassoside in lipid nanocapsules (also called artificial cells), which can not only overcome the characteristics of Madecassoside's instability and easy inactivation, but also play the role of a carrier to improve the transdermal efficiency of Madecassoside, so that more amount of Madecassoside can be delivered to the bottom of the skin to play a role in the skin, and it can significantly enhance the repair effect on damaged skin.

Established in 2000, Green Spring is a leading supplier of botanical extracts in China and has been committed to providing natural, safe, and organic botanical extracts to our customers. All the products we offer are manufactured to the highest international industry standards, complying with EU EC396, EU 2023/915, and the highest solvent residue standards. We have passed Halal, Kosher, COSMOS, BRC, IFS, FDA, ISO, and many other certifications. Authoritative third-party test reports are available.

Specification: 

Regulations:

It conforms to EU regulations.

Benefits:

Soothing

Madecassoside is known to inhibit neutrophils, calm the skin and relieve skin irritation. Neutrophils are the first white blood cells to appear at the site of injury or germ invasion, and they increase after skin allergies. Similarly, if the neutrophils in the skin are effectively suppressed, it indicates a reduction in allergy symptoms.

Repair

Madecassoside can help repair damaged skin tissue, especially in repairing the skin barrier, allergic skin, and chemically burned skin.

Antioxidant

Madecassoside scavenges excess free radicals and has high antioxidant activity. Antioxidant is short for antioxidant free radicals. Excess free radicals accelerate the degradation of elastic fibers, resulting in loss of elasticity and suppleness of the skin. Fighting free radicals can have a slowing effect on aging.

The ABTS + free radical scavenging capacity assay is a commonly used antioxidant capacity assay and is often used to test the antioxidant capacity of cosmetic samples. It can be seen from the above experiments that the scavenging of ABTS + free radicals by 90% of the samples of madecassoside has an antioxidant effect within the tested concentration range of 0.25-2.5 mg/ml. This indicates that it can be used in cosmetic formulations with antioxidant effects.

Anti-inflammatory

Yu-Jen Chen et al. found that Centella Asiatica extract administered at a dermal dose of 16 mg/cm2 had different degrees of therapeutic effects on the skin damage caused by three different intensities of radiation in mice, which was not significantly different from the therapeutic effect of the western medicine Tetrandrine but was 12-15 days earlier than Tetrandrine in reducing the skin reaction, indicating the anti-inflammatory activity of Centella Asiatica extract. However, the skin reaction was reduced 12-15 days earlier than that of Tetrandrine, indicating the anti-inflammatory activity of Centella Asiatica extract. Using this property of Centella Asiatica extract, we can apply it to post-sunburn repair and anti-allergic cosmetics.

Antibacterial

Centella asiatica extract contains asiatic acid and madecassoside, which are active saponins that acidify the cytoplasm of plant cells, thereby protecting the plant itself against molds and yeasts. Experiments have shown that Centella asiatica extract has a certain inhibitory effect on Pseudomonas aeruginosa, Staphylococcus aureus, and Acinetobacter. With this characteristic, Centella asiatica extract powder can be used to treat acne.

Soothing Activity

Centella asiatica extract powder reduces the production of pro-inflammatory mediators (IL-1, MMP-1), and improves and repairs the skin's own barrier function, thus preventing and correcting skin immune disorders. At the same time, Centella Asiatica has an antibacterial effect on Staphylococcus aureus and Proteus mirabilis. With this characteristic, Centella Asiatica extract powder can be used in after-sun repair and anti-allergic cosmetics.

Promote Fibroblast and Collagen Synthesis

Centella Asiatica extract can promote the synthesis of collagen I and III, but also promote the secretion of mucopolysaccharides (such as the synthesis of hyaluronic acid) to increase the skin's water retention; Centella Asiatica extract also has the activation of fibroblast genes, which can enhance the vitality of the skin's basal layer of cells to maintain the skin's elasticity and firmness and to smooth the face of the small wrinkles.

Whitening

The key enzyme for melanin synthesis is tyrosinase, which can catalyze the generation of melanin and other pigments oxidized from tyrosine. Foreign scholars Kwon treated B16F10 cells with different concentrations of Centella Asiatica extract, and the experimental results showed that Centella Asiatica extract could reduce the melanin content in B16F10 cells, and there was a good quantitative relationship. The effect of Centella asiatica extract on tyrosinase protein and mRNA expression was evaluated, and the results showed that Centella Asiatica extract was able to reduce melanin content by inhibiting the expression of tyrosinase protein and mRNA in B16F10 cells. It indicates that Centella Asiatica extract has an inhibitory effect on melanocytes.

Applications:

In Cosmetics:

Modern pharmacological studies have shown that Centella Asiatica extract powder can be added to skin care products as a main ingredient or auxiliary ingredient, with the ability to promote protein synthesis in the skin, scar removal, anti-inflammatory, antioxidant, whitening, and other effects, which can help the skin to maintain a young and healthy state.