10% Icariin Powder

What is Icariin Powder?

Epimedium Extract is a product processed from the dried stems and leaves of Epimediumbrevicornum and other Epimedium species. The main active ingredients are flavonoids, including Epimedium glycoside, Epimedium hypoglycoside, Epimedium grandiflorum glycoside C, and Epimedium asiaticum glycoside A, B, C, and so on. It has an androgen-like effect and is used to improve body immunity and lower blood pressure. It has an obvious inhibitory effect on the infection caused by Staphylococcus aureus and poliovirus. It also has the effect of suppressing cough, expectorant, and asthma. Epimedium extract is mainly used as a raw material for health products to improve sexual function.

Icariin is one of the main active ingredients of Epimedium extract, which is 8-isopentenyl flavonoid glycosides. Epimedium Glycoside can increase cardiovascular blood flow, promote haematopoietic function, immune function, and bone metabolism, and also has the effect of tonifying the kidney and aphrodisiac, anti-aging, and so on.

The icariin powder supplied by Green Spring Technology is a brown to light yellow powder that is made from the local herbs in Longnan, Gansu Province and is produced through more than 20 procedures, such as pre-treatment of herbs, crushing, extracting, concentrating, adsorbing, eluting, spray drying, crushing and sieving. The whole production process adopts all stainless steel production equipment and high-efficiency liquid phase detection equipment for testing. The product has passed the ID test, and heavy metals, solvent residues, microorganisms, and PAHS are in line with the export standards.

Specification:

Regulations:

It conforms to EU regulations.

Benefits:

Sexual Function Enhancement

Icariin is considered to be an effective sexual function enhancer, which can stimulate sexual desire, increase libido, improve erectile function, and is effective in men with erectile dysfunction (ED). Icariin can inhibit ferrous sulfate/hydrogen peroxide-induced oxidative stress damage in human spermatozoa, activate the ERK1 /2 signaling pathway, promote the proliferation of trophoblast Sertoli's in the testis, and enhance the male reproductive function; it can regulate the hypothalamic-pituitary-gonadal axis, up-regulate the expression of dopamine and 5-hydroxytryptophan in the hypothalamus, and activate the PI3K/AKT /eNOS /NO signaling pathway to increase NO, serum testosterone concentration, shorten capture latency and ejaculation latency, increase capture and ejaculation rates as well as testicular and prostate indices, and improve the sexual function of male mice; it can activate NO-cyclic guanosine monophosphate signaling pathway, inhibit the expression of phosphodiesterase type 5, and improve erectile dysfunction.

Beneficial for Neurological Disorders     

Icariin is beneficial in a variety of neurological disorders such as cerebral ischaemia, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and depression. Icariin can increase the level of superoxide dismutase (SOD). Decrease the expression of amyloid precursor protein and β-secretase, and reduce the production and accumulation of Aβ. It can also reduce Aβ-mediated atrophy of axons and dendrites, and improve the spatial learning and memory ability of Alzheimer's disease model rats. Icariin can also inhibit Aβ-induced hyperphosphorylation of serine 396, 404, and threonine 205 of tau protein. Thus, it can play the role of protecting nerve cells.

Protecting the Skeletal System

Icariin can promote the formation and activation of osteoblasts and inhibit the formation and function of osteoclasts to alleviate osteoporosis. Icariin can activate ERα-Wnt/β-catenin and Notch signaling pathway, and up-regulate the expression of runt-related transcription factor 2, a key gene in osteoblasts, to play the role of osteogenesis. It can activate the mitogen-activated protein kinase (MAPK) signaling pathway and increase the gene expression of type I collagen, osteocalcin, and osteopontin. Enhance the self-renewal capacity of bone mesenchymal stem cells (BMSCs) in vivo and in vitro. Induces the differentiation of BMSCs to osteoblasts, which in turn enhances osteogenic differentiation. In addition, Icariin can promote estrogen synthesis and has estrogen-like effects. It can activate extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), and promote the proliferation of osteoblasts. Activates BMP-2/Smad4 to increase osteoblast viability.

Protection of the Cardiovascular System  

Icariin can block angiotensin II-induced cardiomyocyte hypertrophy and apoptosis by inhibiting the activation of JNK and p38 pathways. It activates ERK, removes reactive oxygen species, and inhibits oxidative stress in cardiomyocytes. Icariin also activates the PI3K/Akt/endothelial nitric oxide synthase (eNOS) signaling pathway and reduces creatine kinase. Ischemic modification of albumin and lactate dehydrogenase levels reduced apoptotic cells, myocardial infarction area, and ameliorated myocardial ischemia-reperfusion injury in rats. Down-regulates matrix metalloproteinase 2 and 9 activities, improves cardiomyocyte apoptosis and attenuates left ventricular dysfunction and cardiac remodeling.

Regulating the Immune System

Icariin can improve the condition of autoimmune diseases such as rheumatoid arthritis, bronchial asthma, multiple sclerosis, and systemic lupus erythematosus, which is related to its regulation of lymphocyte function. Icariin can inhibit the differentiation of helper T cells (Th) 1 and 17, and improve autoimmune encephalomyelitis in mice. Icariin can inhibit the activation of STAT3 in T cells and down-regulate the proportion of Th17 cells. It can inhibit the production of interleukin-17 and improve the symptoms of rheumatoid arthritis. It can regulate the ratio of Th1/Th2 cells in lung tissues of asthmatic rats and the balance of Th17/regulatory T cells in asthmatic mice, and improve asthma. It can increase the activity of lymphokine-activated killer cells as well as natural killer cells to improve human immunity.

Applications:

For Feed Product:

Test results show that adding Epimedium Extract to the feed promotes the development of the thymus, spleen, and bursa, improves the effect of vaccines for Newcastle Disease and Avian Influenza, strengthens immunity, improves resistance to infectious diseases, and reduces the mortality rate as well as the morbidity rate. Epimedium Extract Icariin has anti-respiratory syndrome. It has been verified by tests that adding Epimedium Extract to feed can prevent and control epidemic diarrhoea in pigs. Rapidly regulate the intestinal physiological function of female animals and optimize the intestinal environment. Improve the reproductive ability of sows and promote the growth of animals.

For Health Product:

Epimedium extract has the effect of enhancing gonadal function, regulating body's immune function, promoting bone growth, delaying aging, and so on. Epimedoside powder is used as a raw material in health products.